Ontology highlight
ABSTRACT:
SUBMITTER: Scheffner M
PROVIDER: S-EPMC44693 | biostudies-other | 1994 Sep
REPOSITORIES: biostudies-other
Scheffner M M Huibregtse J M JM Howley P M PM
Proceedings of the National Academy of Sciences of the United States of America 19940901 19
The E6 protein of the oncogenic human papillomavirus types 16 and 18 facilitates the rapid degradation of the tumor-suppressor protein p53 via the ubiquitin-dependent proteolytic pathway. The E6 protein binds to a cellular protein of 100 kDa termed E6-AP. The complex of E6 and E6-AP specifically interacts with p53 and induces the ubiquitination of p53 in a reaction which requires the ubiquitin-activating enzyme (E1) and a cellular fraction thought to contain a mammalian ubiquitin-conjugating enz ...[more]