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DAS181 treatment of hematopoietic stem cell transplant patients with parainfluenza virus lung disease requiring mechanical ventilation.

ABSTRACT: Parainfluenza infection is a cause of significant morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) patients. DAS181 is a novel antiviral agent with activity against influenza and parainfluenza. We report the first 2 cases, to our knowledge, of successful DAS181 use in ventilated HSCT patients with severe parainfluenza lung disease.

SUBMITTER: Chalkias S

PROVIDER: S-EPMC4469988 | biostudies-other | 2014 Feb

REPOSITORIES: biostudies-other

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DAS181 treatment of hematopoietic stem cell transplant patients with parainfluenza virus lung disease requiring mechanical ventilation.

Chalkias S S Mackenzie M R MR Gay C C Dooley C C Marty F M FM Moss R B RB Li T T Routh R L RL Walsh S R SR Tan C S CS

Transplant infectious disease : an official journal of the Transplantation Society 20140103 1

Parainfluenza infection is a cause of significant morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) patients. DAS181 is a novel antiviral agent with activity against influenza and parainfluenza. We report the first 2 cases, to our knowledge, of successful DAS181 use in ventilated HSCT patients with severe parainfluenza lung disease. ...[more]

PMID: 24383501

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