Ontology highlight
ABSTRACT:
SUBMITTER: Zeitlin R
PROVIDER: S-EPMC4470200 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Zeitlin Ross R Nguyen Harrison P HP Rafferty David D Tyring Stephen S
Journal of clinical medicine 20150424 5
Head and neck carcinomas have long been linked to alcohol and tobacco abuse; however, within the last two decades, the human papillomavirus (HPV) has emerged as a third etiology and is specifically associated with head and neck squamous cell carcinomas (HNSCC). In this anatomical region, the oncogenic HPV-16 mediates transformation and immortalization of epithelium, most commonly in the oropharynx. Nevertheless, the recent identification of novel HPV mechanisms thought to be specific to orophary ...[more]