Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes.
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SUBMITTER: James S
PROVIDER: S-EPMC4471830 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
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Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes.
James Sally S Fox James J Afsari Farinaz F Lee Jennifer J Clough Sally S Knight Charlotte C Ashmore James J Ashton Peter P Preham Olivier O Hoogduijn Martin M Ponzoni Raquel De Almeida Rocha Rde A Hancock Y Y Coles Mark M Genever Paul P
Stem cell reports 20150601 6
Bone marrow stromal cells (BMSCs, also called bone-marrow-derived mesenchymal stromal cells) provide hematopoietic support and immunoregulation and contain a stem cell fraction capable of skeletogenic differentiation. We used immortalized human BMSC clonal lines for multi-level analysis of functional markers for BMSC subsets. All clones expressed typical BMSC cell-surface antigens; however, clones with trilineage differentiation capacity exhibited enhanced vascular interaction gene sets, whereas ...[more]
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