Renal endothelial injury and microvascular dysfunction in acute kidney injury.
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ABSTRACT:
SUBMITTER: Verma SK
PROVIDER: S-EPMC4476528 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Publications
Renal endothelial injury and microvascular dysfunction in acute kidney injury.
Verma Sudhanshu Kumar SK Molitoris Bruce A BA
Seminars in nephrology 20150101 1
The kidney is comprised of heterogeneous cell populations that function together to perform a number of tightly controlled, complex and interdependent processes. Renal endothelial cells contribute to vascular tone, regulation of blood flow to local tissue beds, modulation of coagulation and inflammation, and vascular permeability. Both ischemia and sepsis have profound effects on the renal endothelium, resulting in microvascular dysregulation resulting in continued ischemia and further injury. I ...[more]
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