Ontology highlight
ABSTRACT:
SUBMITTER: Sims S
PROVIDER: S-EPMC4477908 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
European journal of immunology 20141117 1
Murine CMV (MCMV) infection induces effector CD8(+) T cells that continue to increase in frequency after acute infection ("inflation") and are stably maintained at a high frequency, with up to 20% of the CD8(+) T-cell compartment being specific for one epitope, although the flexibility and turnover of these populations is not fully defined. Here we report that effector/memory CD8(+) T cells induced by MCMV can be paradoxically boosted following transient depletion of epitope specific CD8(+) T ce ...[more]