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Differential Evolution approach to detect recent admixture.


ABSTRACT: The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual's knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.

SUBMITTER: Kozlov K 

PROVIDER: S-EPMC4480842 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Differential Evolution approach to detect recent admixture.

Kozlov Konstantin K   Chebotarev Dmitri D   Hassan Mehedi M   Triska Martin M   Triska Petr P   Flegontov Pavel P   Tatarinova Tatiana V TV  

BMC genomics 20150618


The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeo  ...[more]

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