Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.
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ABSTRACT:
SUBMITTER: Gearing M
PROVIDER: S-EPMC44816 | biostudies-other | 1994 Sep
REPOSITORIES: biostudies-other
Publications
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.
Gearing M M Rebeck G W GW Hyman B T BT Tigges J J Mirra S S SS
Proceedings of the National Academy of Sciences of the United States of America 19940901 20
Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease. Senile plaques and blood vessels were immunoreactive for amyloid beta-protein and apolipoprotein E (apoE) in the nonhuman primates, recapitulating findings in human aging and Alzheimer disease. Neurofibrillary tangles, another hallmark of Alzheimer disease, were absent. PCR/restriction-enzyme analysis in chimpanzees revealed an APOE profile similar to the human ...[more]
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