Ontology highlight
ABSTRACT:
SUBMITTER: Ariosa A
PROVIDER: S-EPMC4485088 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20150608 25
The ribosome exit site is a crowded environment where numerous factors contact nascent polypeptides to influence their folding, localization, and quality control. Timely and accurate selection of nascent polypeptides into the correct pathway is essential for proper protein biogenesis. To understand how this is accomplished, we probe the mechanism by which nascent polypeptides are accurately sorted between the major cotranslational chaperone trigger factor (TF) and the essential cotranslational t ...[more]