Positing, fitting, and selecting regression models for pooled biomarker data.
Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell EM
PROVIDER: S-EPMC4490092 | biostudies-other | 2015 Jul
REPOSITORIES: biostudies-other
Publications
Positing, fitting, and selecting regression models for pooled biomarker data.
Mitchell Emily M EM Lyles Robert H RH Schisterman Enrique F EF
Statistics in medicine 20150406 17
Pooling biospecimens prior to performing lab assays can help reduce lab costs, preserve specimens, and reduce information loss when subject to a limit of detection. Because many biomarkers measured in epidemiological studies are positive and right-skewed, proper analysis of pooled specimens requires special methods. In this paper, we develop and compare parametric regression models for skewed outcome data subject to pooling, including a novel parameterization of the gamma distribution that takes ...[more]
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