Unknown

Dataset Information

0

Enantiomer-specific analysis of multi-component mixtures by correlated electron imaging-ion mass spectrometry.


ABSTRACT: Simultaneous, enantiomer-specific identification of chiral molecules in multi-component mixtures is extremely challenging. Many established techniques for single-component analysis fail to provide selectivity in multi-component mixtures and lack sensitivity for dilute samples. Here we show how enantiomers may be differentiated by mass-selected photoelectron circular dichroism using an electron-ion coincidence imaging spectrometer. As proof of concept, vapours containing ?1% of two chiral monoterpene molecules, limonene and camphor, are irradiated by a circularly polarized femtosecond laser, resulting in multiphoton near-threshold ionization with little molecular fragmentation. Large chiral asymmetries (2-4%) are observed in the mass-tagged photoelectron angular distributions. These asymmetries switch sign according to the handedness (R- or S-) of the enantiomer in the mixture and scale with enantiomeric excess of a component. The results demonstrate that mass spectrometric identification of mixtures of chiral molecules and quantitative determination of enantiomeric excess can be achieved in a table-top instrument.

SUBMITTER: Fanood MM 

PROVIDER: S-EPMC4491818 | biostudies-other | 2015

REPOSITORIES: biostudies-other

altmetric image

Publications

Enantiomer-specific analysis of multi-component mixtures by correlated electron imaging-ion mass spectrometry.

Fanood Mohammad M Rafiee MM   Ram N Bhargava NB   Lehmann C Stefan CS   Powis Ivan I   Janssen Maurice H M MH  

Nature communications 20150624


Simultaneous, enantiomer-specific identification of chiral molecules in multi-component mixtures is extremely challenging. Many established techniques for single-component analysis fail to provide selectivity in multi-component mixtures and lack sensitivity for dilute samples. Here we show how enantiomers may be differentiated by mass-selected photoelectron circular dichroism using an electron-ion coincidence imaging spectrometer. As proof of concept, vapours containing ∼1% of two chiral monoter  ...[more]

Similar Datasets

| S-EPMC7765731 | biostudies-literature
| S-EPMC6811541 | biostudies-literature
| S-EPMC7806562 | biostudies-literature
| S-EPMC8109779 | biostudies-literature
| S-EPMC7343235 | biostudies-literature
2016-11-15 | GSE89818 | GEO
| S-EPMC3946938 | biostudies-literature
| S-EPMC4049834 | biostudies-literature
| S-EPMC4287836 | biostudies-other
| S-EPMC10901485 | biostudies-literature