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Exosomes released by keratinocytes modulate melanocyte pigmentation.

ABSTRACT: Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states.

SUBMITTER: Lo Cicero A

PROVIDER: S-EPMC4491833 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Exosomes released by keratinocytes modulate melanocyte pigmentation.

Lo Cicero Alessandra A Delevoye Cédric C Gilles-Marsens Floriane F Loew Damarys D Dingli Florent F Guéré Christelle C André Nathalie N Vié Katell K van Niel Guillaume G Raposo Graça G

Nature communications 20150624

Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent ...[more]

PMID: 26103923

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