Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC4494668 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Zhang Weiqi W Li Jingyi J Suzuki Keiichiro K Qu Jing J Wang Ping P Zhou Junzhi J Liu Xiaomeng X Ren Ruotong R Xu Xiuling X Ocampo Alejandro A Yuan Tingting T Yang Jiping J Li Ying Y Shi Liang L Guan Dee D Pan Huize H Duan Shunlei S Ding Zhichao Z Li Mo M Yi Fei F Bai Ruijun R Wang Yayu Y Chen Chang C Yang Fuquan F Li Xiaoyu X Wang Zimei Z Aizawa Emi E Goebl April A Soligalla Rupa Devi RD Reddy Pradeep P Esteban Concepcion Rodriguez CR Tang Fuchou F Liu Guang-Hui GH Belmonte Juan Carlos Izpisua JC
Science (New York, N.Y.) 20150430 6239
Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). Differentiation of WRN-null ESCs to mesenchymal stem cells (MSCs) recapitulates features of premature cellular aging, a global loss of H3K9me3, and changes in heterochromatin architecture. We show that WRN associates with heterochromatin proteins SUV39H1 and HP1α and nuclear lamina-heterochromatin anchoring protein LAP2β. ...[more]