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HIV and HCV Medications in End-Stage Renal Disease.

ABSTRACT: Human immunodeficiency virus (HIV) infection and hepatitis C virus (HCV) infection affect populations worldwide. With the availability of over 35 Food and Drug Administration approved medications for treatment of HIV, the morbidity and mortality associated with HIV has greatly improved. On the other hand, treatment options for HCV have been limited until very recently. While the use of protease inhibitors (such as boceprevir and telaprevir) has become standard of care for treatment of hepatitis C in the general population, data for individuals with impaired kidney function, particularly those on dialysis, are extremely limited. Use of medications in dialysis patients can be challenging given the dose adjustments that must be made for renally cleared molecules, and potentially increased impact of adverse effects such as anemia. Recommendations for dosing of marketed therapies for HIV and HCV are reviewed.

SUBMITTER: Greenberg KI

PROVIDER: S-EPMC4496266 | biostudies-other | 2015 Jul-Aug

REPOSITORIES: biostudies-other

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HIV and HCV Medications in End-Stage Renal Disease.

Greenberg Keiko I KI Perazella Mark A MA Atta Mohamed G MG

Seminars in dialysis 20150406 4

Human immunodeficiency virus (HIV) infection and hepatitis C virus (HCV) infection affect populations worldwide. With the availability of over 35 Food and Drug Administration approved medications for treatment of HIV, the morbidity and mortality associated with HIV has greatly improved. On the other hand, treatment options for HCV have been limited until very recently. While the use of protease inhibitors (such as boceprevir and telaprevir) has become standard of care for treatment of hepatitis ...[more]

PMID: 25845407

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Dataset Information

HIV and HCV Medications in End-Stage Renal Disease.

Publications

HIV and HCV Medications in End-Stage Renal Disease.

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