Ontology highlight
ABSTRACT:
SUBMITTER: Cho JH
PROVIDER: S-EPMC4496341 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
Cho Jung-Hyun JH Lee Su-Jin SJ Oh Ah-Young AY Yoon Min-Ho MH Woo Tae-Geun TG Park Bum-Joon BJ
Oncotarget 20150401 12
Although asbestos causes malignant pleural mesothelioma (MPM), rising from lung mesothelium, the molecular mechanism has not been suggested until now. Extremely low mutation rate in classical tumor suppressor genes (such as p53 and pRb) and oncogenes (including Ras or myc) indicates that there would be MPM-specific carcinogenesis pathway. To address this, we treated silica to mimic mesothelioma carcinogenesis in mesothelioma and non-small cell lung cancer cell lines (NSCLC). Treatment of silica ...[more]