Robust meta-analysis of gene expression using the elastic net.
Ontology highlight
ABSTRACT:
SUBMITTER: Hughey JJ
PROVIDER: S-EPMC4499117 | biostudies-other | 2015 Jul
REPOSITORIES: biostudies-other
Publications
Robust meta-analysis of gene expression using the elastic net.
Hughey Jacob J JJ Butte Atul J AJ
Nucleic acids research 20150331 12
Meta-analysis of gene expression has enabled numerous insights into biological systems, but current methods have several limitations. We developed a method to perform a meta-analysis using the elastic net, a powerful and versatile approach for classification and regression. To demonstrate the utility of our method, we conducted a meta-analysis of lung cancer gene expression based on publicly available data. Using 629 samples from five data sets, we trained a multinomial classifier to distinguish ...[more]
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