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ECG Prediction Based on Classification via Neural Networks and Linguistic Fuzzy Logic Forecaster.

ABSTRACT: The paper deals with ECG prediction based on neural networks classification of different types of time courses of ECG signals. The main objective is to recognise normal cycles and arrhythmias and perform further diagnosis. We proposed two detection systems that have been created with usage of neural networks. The experimental part makes it possible to load ECG signals, preprocess them, and classify them into given classes. Outputs from the classifiers carry a predictive character. All experimental results from both of the proposed classifiers are mutually compared in the conclusion. We also experimented with the new method of time series transparent prediction based on fuzzy transform with linguistic IF-THEN rules. Preliminary results show interesting results based on the unique capability of this approach bringing natural language interpretation of particular prediction, that is, the properties of time series.

SUBMITTER: Volna E

PROVIDER: S-EPMC4499654 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Project description:BackgroundTo date, only a limited number of transcriptional regulatory interactions have been uncovered. In a pilot study integrating sequence data with microarray data, a position weight matrix (PWM) performed poorly in inferring transcriptional interactions (TIs), which represent physical interactions between transcription factors (TF) and upstream sequences of target genes. Inferring a TI means that the promoter sequence of a target is inferred to match the consensus sequence motifs of a potential TF, and their interaction type such as AT or RT is also predicted. Thus, a robust PWM (rPWM) was developed to search for consensus sequence motifs. In addition to rPWM, one feature extracted from ChIP-chip data was incorporated to identify potential TIs under specific conditions. An interaction type classifier was assembled to predict activation/repression of potential TIs using microarray data. This approach, combining an adaptive (learning) fuzzy inference system and an interaction type classifier to predict transcriptional regulatory networks, was named AdaFuzzy.ResultsAdaFuzzy was applied to predict TIs using real genomics data from Saccharomyces cerevisiae. Following one of the latest advances in predicting TIs, constrained probabilistic sparse matrix factorization (cPSMF), and using 19 transcription factors (TFs), we compared AdaFuzzy to four well-known approaches using over-representation analysis and gene set enrichment analysis. AdaFuzzy outperformed these four algorithms. Furthermore, AdaFuzzy was shown to perform comparably to 'ChIP-experimental method' in inferring TIs identified by two sets of large scale ChIP-chip data, respectively. AdaFuzzy was also able to classify all predicted TIs into one or more of the four promoter architectures. The results coincided with known promoter architectures in yeast and provided insights into transcriptional regulatory mechanisms.ConclusionAdaFuzzy successfully integrates multiple types of data (sequence, ChIP, and microarray) to predict transcriptional regulatory networks. The validated success in the prediction results implies that AdaFuzzy can be applied to uncover TIs in yeast.

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ECG Prediction Based on Classification via Neural Networks and Linguistic Fuzzy Logic Forecaster.

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