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Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to ?-Lactam Antibiotics.

ABSTRACT: We show here that a series of triazolyl glycolipid derivatives modularly synthesized by a "click" reaction have the ability to increase the susceptibility of a drug-resistant bacterium to ?-lactam antibiotics. We determine that the glycolipids can suppress the minimal inhibitory concentration of a number of ineffective ?-lactams, upward of 256-fold, for methicillin-resistant Staphylococuss aureus (MRSA). The mechanism of action has been preliminarily probed and discussed.

SUBMITTER: Hu XL 

PROVIDER: S-EPMC4499819 | biostudies-other | 2015 Jul

REPOSITORIES: biostudies-other

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Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.

Hu Xi-Le XL   Li Dan D   Shao Lei L   Dong Xiaojing X   He Xiao-Peng XP   Chen Guo-Rong GR   Chen Daijie D  

ACS medicinal chemistry letters 20150601 7

We show here that a series of triazolyl glycolipid derivatives modularly synthesized by a "click" reaction have the ability to increase the susceptibility of a drug-resistant bacterium to β-lactam antibiotics. We determine that the glycolipids can suppress the minimal inhibitory concentration of a number of ineffective β-lactams, upward of 256-fold, for methicillin-resistant Staphylococuss aureus (MRSA). The mechanism of action has been preliminarily probed and discussed. ...[more]