Ontology highlight
ABSTRACT:
SUBMITTER: Matsui T
PROVIDER: S-EPMC450144 | biostudies-other | 1996 May
REPOSITORIES: biostudies-other
Matsui T T Amano M M Yamamoto T T Chihara K K Nakafuku M M Ito M M Nakano T T Okawa K K Iwamatsu A A Kaibuchi K K
The EMBO journal 19960501 9
The small GTP binding protein Rho is implicated in cytoskeletal responses to extracellular signals such as lysophosphatidic acid to form stress fibers and focal contacts. Here we have purified a Rho-interacting protein with a molecular mass of approximately 164 kDa (p164) from bovine brain. This protein bound to GTPgammaS (a non-hydrolyzable GTP analog).RhoA but not to GDP.RhoA or GTPgammaS.RhoA with a mutation in the effector domain (RhoAA37).p164 had a kinase activity which was specifically st ...[more]