Ontology highlight
ABSTRACT:
SUBMITTER: Prentice S
PROVIDER: S-EPMC4503799 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Prentice Sarah S Jallow Momodou W MW Prentice Andrew M AM
Vaccine 20150507 26
Bacillus Calmette-Guerin (BCG) vaccination has been reported to protect neonates from non-tuberculous pathogens, but no biological mechanism to explain such effects is known. We hypothesised that BCG produces broad-spectrum anti-microbial protection via a hepcidin-mediated hypoferraemia, limiting iron availability for pathogens. To test this we conducted a trial in 120 Gambian neonates comparing iron status in the first 5-days of life after allocation to: (1) All routine vaccinations at birth (B ...[more]