Ontology highlight
ABSTRACT:
SUBMITTER: Dua P
PROVIDER: S-EPMC4505827 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Dua P P Hawkins E E van der Graaf P H PH
CPT: pharmacometrics & systems pharmacology 20150615 6
Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna2 code for some models discussed in this Tutorial are provided in the Supplementary Materials. ...[more]