Ontology highlight
ABSTRACT:
SUBMITTER: Guo H
PROVIDER: S-EPMC4506778 | biostudies-other | 2015 May
REPOSITORIES: biostudies-other
Guo Hao H Zhang Jialong J Zhang Xuyuan X Wang Yanbing Y Yu Haisheng H Yin Xiangyun X Li Jingyun J Du Peishuang P Plumas Joel J Chaperot Laurence L Chen Jianzhu J Su Lishan L Liu Yongjun Y Zhang Liguo L
Journal of immunology (Baltimore, Md. : 1950) 20150410 10
Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blood cells, SCARB2 is most highly expressed in plasmacytoid dendritic cells (pDCs), and its expression is further upregulated by CpG oligodeoxynucleotide stimulation. Knockdown of SCARB2 in pDC cell lin ...[more]