Important mitochondrial proteins in human omental adipose tissue show reduced expression in obesity.
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ABSTRACT:
SUBMITTER: Lindinger PW
PROVIDER: S-EPMC4510373 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Publications
Important mitochondrial proteins in human omental adipose tissue show reduced expression in obesity.
Lindinger Peter W PW Christe Martine M Eberle Alex N AN Kern Beatrice B Peterli Ralph R Peters Thomas T Jayawardene Kamburapola J I KJ Fearnley Ian M IM Walker John E JE
Data in brief 20150423
Obesity is associated with impaired mitochondrial function. This study compares mitochondrial protein expression in omental fat in obese and non-obese humans. Omental adipose tissue was obtained by surgical biopsy, adipocytes were purified and mitochondria isolated. Using anion-exchange chromatography, SDS-PAGE and mass-spectrometry, 128 proteins with potentially different abundances in patient groups were identified, 62 of the 128 proteins are mainly localized in the mitochondria. Further quant ...[more]
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