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Therapeutic options in other metabolic myopathies.


ABSTRACT: Adult patients with metabolic myopathies typically present with exercise-induced pain, cramps, fatigue, and myoglobinuria. The current therapeutic options of glycogen and lipid storage myopathies include dietary treatments, excersise training, and pharmacological supplementations. Herein is a review of evidence from randomized controlled trials in McArdle disease (glycogen storage disease type V, muscle phosphorylase deficiency) and carnitine palmitoyltransferase (CPT) 2 deficiency. A brief overview on current treatment options in rhabdomyolysis is also included because patients with McArdle disease and CPT 2 often experience such potentially life-threatening complications.

SUBMITTER: Vorgerd M 

PROVIDER: S-EPMC4514707 | biostudies-other | 2008 Oct

REPOSITORIES: biostudies-other

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Therapeutic options in other metabolic myopathies.

Vorgerd Matthias M  

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20081001 4


Adult patients with metabolic myopathies typically present with exercise-induced pain, cramps, fatigue, and myoglobinuria. The current therapeutic options of glycogen and lipid storage myopathies include dietary treatments, excersise training, and pharmacological supplementations. Herein is a review of evidence from randomized controlled trials in McArdle disease (glycogen storage disease type V, muscle phosphorylase deficiency) and carnitine palmitoyltransferase (CPT) 2 deficiency. A brief over  ...[more]

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