Ontology highlight
ABSTRACT:
SUBMITTER: Sasai Y
PROVIDER: S-EPMC452184 | biostudies-other | 1996 Sep
REPOSITORIES: biostudies-other
The EMBO journal 19960901 17
Spemann's organizer has potent neural inducing and mesoderm dorsalizing activities in the Xenopus gastrula. A third activity, the organizer's ability to induce a secondary gut, has been difficult to analyze experimentally due to the lack of early gene markers. Here we introduce endodermin, a pan-endodermal gene marker, and use it to demonstrate that chordin (Chd), a protein secreted by the organizer region, is able to induce endodermal differentiation in Xenopus. The ability of chd, as well as t ...[more]