Ontology highlight
ABSTRACT:
SUBMITTER: Adachi N
PROVIDER: S-EPMC4523857 | biostudies-other | 2015 Aug
REPOSITORIES: biostudies-other
Adachi Naoki N Numakawa Tadahiro T Nakajima Shingo S Fukuoka Masashi M Odaka Haruki H Katanuma Yusuke Y Ooshima Yoshiko Y Hohjoh Hirohiko H Kunugi Hiroshi H
Scientific reports 20150804
Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation, and functions in the central nervous system (CNS). Because BDNF protein is sorted into secretory vesicles at the trans-Golgi network in the cell body after translation, transport of BDNF-containing vesicles to the secretion sites is an important process for its function. Here we examined the effect of dexamethasone (DEX), a synthetic glucocorticoid, on BDNF-containing vesicle transport and found that DE ...[more]