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Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes.

ABSTRACT: A Rh-catalyst system based on the asymmetric ligand (t)Bu2PCH2P(o-C6H4OMe)2 is reported that allows for the hydroacylation of challenging internal alkenes with ?-substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe-group.

SUBMITTER: Prades A

PROVIDER: S-EPMC4531818 | biostudies-other | 2015 Jul

REPOSITORIES: biostudies-other

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Well-Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes.

Prades Amparo A Fernández Maitane M Pike Sebastian D SD Willis Michael C MC Weller Andrew S AS

Angewandte Chemie (International ed. in English) 20150609 29

A Rh-catalyst system based on the asymmetric ligand (t)Bu2PCH2P(o-C6H4OMe)2 is reported that allows for the hydroacylation of challenging internal alkenes with β-substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe-group. ...[more]

PMID: 26069052

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