Unknown

Dataset Information

0

Primary intraocular synovial sarcoma in the post retinal detachment operative state.


ABSTRACT: Synovial sarcoma generally arises in the deep soft tissue, although it has been described at virtually every anatomic site except in the eyeball. We report the case of a 48-year-old woman who had a history of retinal detachment surgery and who had undergone vitrectomy and the insertion of a solid silicon explant 24 years previously. She reported a visual field defect. Funduscopy and MRI revealed a tumour just behind the iris in the left eyeball, and enucleation was performed. Microscopic examination of the tumour revealed uniform spindle cells in a fascicular arrangement with frequent mitotic figures. Immunohistochemistry showed that the tumour was positive for TLE1 and epithelial membrane antigen and fluorescent in situ hybridisation revealed that the tumour had a rearrangement of the SYT gene. Reverse transcription (RT)-PCR confirmed the presence of a SYT-SSX2 fusion transcript. On the basis of these histomorphological and molecular features, the diagnosis of poorly differentiated synovial sarcoma was rendered.

SUBMITTER: Ito J 

PROVIDER: S-EPMC4533628 | biostudies-other | 2015 Aug

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC10176194 | biostudies-literature
| S-EPMC9434647 | biostudies-literature
| S-EPMC5811744 | biostudies-literature
| S-EPMC8144357 | biostudies-literature
| S-EPMC5127550 | biostudies-literature
| S-EPMC6305143 | biostudies-literature
| S-EPMC8298838 | biostudies-literature
| S-EPMC4348461 | biostudies-literature
| S-EPMC3745145 | biostudies-literature
| S-EPMC7086378 | biostudies-literature