Ontology highlight
ABSTRACT:
SUBMITTER: Broomall E
PROVIDER: S-EPMC4534165 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
Annals of neurology 20141111 6
Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic γ-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolon ...[more]