The histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b.
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ABSTRACT:
SUBMITTER: Ma Q
PROVIDER: S-EPMC4539089 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Publications
The histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b.
Ma Qiang Q Chen Zhuo Z Jia Guojin G Lu Xueqiang X Xie Xuefeng X Jin Wei W
OncoTargets and therapy 20150810
<h4>Aims</h4>Prostate cancer (PCa) is the most frequently diagnosed malignancy in men. However, the underlying mechanism is not fully understood. In this study, we aim to research the molecular mechanisms underlying the initiation and progression of PCa.<h4>Results</h4>Plant homeodomain finger protein 8 (PHF8) is upregulated in human PCa tissues and cell lines. PHF8 knockdown attenuates growth and cellular transformation of PCa cells. PHF8 depletion induces PCa cell apoptosis by activating proap ...[more]
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