Ontology highlight
ABSTRACT:
SUBMITTER: Simon CM
PROVIDER: S-EPMC4541707 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Simon Christian M CM Rauskolb Stefanie S Gunnersen Jennifer M JM Holtmann Bettina B Drepper Carsten C Dombert Benjamin B Braga Massimiliano M Wiese Stefan S Jablonka Sibylle S Pühringer Dirk D Zielasek Jürgen J Hoeflich Andreas A Silani Vincenzo V Wolf Eckhard E Kneitz Susanne S Sommer Claudia C Toyka Klaus V KV Sendtner Michael M
Acta neuropathologica 20150530 3
Diabetic neuropathy (DNP), afflicting sensory and motor nerve fibers, is a major complication in diabetes. The underlying cellular mechanisms of axon degeneration are poorly understood. IGFBP5, an inhibitory binding protein for insulin-like growth factor 1 (IGF1) is highly up-regulated in nerve biopsies of patients with DNP. We investigated the pathogenic relevance of this finding in transgenic mice overexpressing IGFBP5 in motor axons and sensory nerve fibers. These mice develop motor axonopath ...[more]