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Our Fat Future: Translating Adipose Stem Cell Therapy.


ABSTRACT: Human adipose stem cells (hASCs) have the potential to treat patients with a variety of clinical conditions. Recent advancements in translational research, regulatory policy, and industry have positioned hASCs on the threshold of clinical translation. We discuss the progress and challenges of bringing adipose stem cell therapy into mainstream clinical use.This article details the advances made in recent years that have helped move human adipose stem cell therapy toward mainstream clinical use from a translational research, regulatory policy, and industrial standpoint. Four recurrent themes in translational technology as they pertain to human adipose stem cells are discussed: automated closed-system operations, biosensors and real-time monitoring, biomimetics, and rapid manufacturing. In light of recent FDA guidance documents, regulatory concerns about adipose stem cell therapy are discussed. Finally, an update is provided on the current state of clinical trials and the emerging industry that uses human adipose stem cells. This article is expected to stimulate future studies in translational adipose stem cell research.

SUBMITTER: Nordberg RC 

PROVIDER: S-EPMC4542878 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other

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Our Fat Future: Translating Adipose Stem Cell Therapy.

Nordberg Rachel C RC   Loboa Elizabeth G EG  

Stem cells translational medicine 20150716 9


<h4>Unlabelled</h4>Human adipose stem cells (hASCs) have the potential to treat patients with a variety of clinical conditions. Recent advancements in translational research, regulatory policy, and industry have positioned hASCs on the threshold of clinical translation. We discuss the progress and challenges of bringing adipose stem cell therapy into mainstream clinical use.<h4>Significance</h4>This article details the advances made in recent years that have helped move human adipose stem cell t  ...[more]

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