Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC4552489 | biostudies-other | 2015 Aug
REPOSITORIES: biostudies-other
EMBO reports 20150629 8
Silencing of transposable elements (TEs) in the metazoan germline is critical for genome integrity and is primarily dependent on Piwi proteins and associated RNAs, which exert their function through both transcriptional and posttranscriptional mechanisms. Here, we report that the evolutionarily conserved Pelo (Dom34)-Hbs1 mRNA surveillance complex is required for transposon silencing in the Drosophila germline. In pelo mutant gonads, mRNAs and proteins of some selective TEs are up-regulated. Pel ...[more]