Ontology highlight
ABSTRACT:
SUBMITTER: Foster DC
PROVIDER: S-EPMC45573 | biostudies-other | 1994 Dec
REPOSITORIES: biostudies-other
Foster D C DC Sprecher C A CA Grant F J FJ Kramer J M JM Kuijper J L JL Holly R D RD Whitmore T E TE Heipel M D MD Bell L A LA Ching A F AF
Proceedings of the National Academy of Sciences of the United States of America 19941201 26
Thrombopoietin (TPO), a lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from committed progenitor cells, is believed to be the major physiological regulator of circulating platelet levels. Recently we have isolated a cDNA encoding a ligand for the murine c-mpl protooncogene and shown it to be TPO. By employing a murine cDNA probe, we have isolated a gene encoding human TPO from a human genomic library. The TPO locus spans over 6 kb and has a structure simil ...[more]