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Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast.


ABSTRACT: We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain.

SUBMITTER: Zheng B 

PROVIDER: S-EPMC4566119 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other

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