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Evaluation of hepatic perfusion in the liver graft using fluorescence imaging with indocyanine green.


ABSTRACT: Portal vein thrombosis (PVT) after liver transplantation (LT) is one of serious complications and reportedly ranges from 2% to 13%. PVT impairs the blood perfusion to the grafts and causes the graft dysfunction.A 60-year-old female underwent living-donor LT with the left liver graft for end-stage liver disease related to chronic hepatitis C. After reperfusion, Indocyanine green (ICG)-fluorescence imaging was performed to confirm the graft perfusion, which pointed out an insufficient perfusion on the surface of segment 4. Following intraoperative ultrasonography revealed thrombus in the portal vein of segment 4, which was successfully removed by heparinized saline flush.The most of patients with PVT developed graft failure and resulted in retransplantation. This enhances the importance of the surveillance for PVT in the postoperative period as well as the intraoperative period. However, the modality to identify PVT during surgery is limited mainly to intraoperative ultrasound. ICG-fluorescence imaging can visualize regions with impaired hepatic perfusion due to PVT in real time during LT in addition to visualization of hepatic flows of reconstructed vessels and evaluation of regions with venous occlusion.ICG-fluorescence imaging can be simply performed with single ICG injection and is expected to have potential roles to enhance the safety of LT.

SUBMITTER: Kawaguchi Y 

PROVIDER: S-EPMC4573850 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Evaluation of hepatic perfusion in the liver graft using fluorescence imaging with indocyanine green.

Kawaguchi Yoshikuni Y   Akamatsu Nobuhisa N   Ishizawa Takeaki T   Kaneko Junichi J   Arita Junichi J   Sakamoto Yoshihiro Y   Hasegawa Kiyoshi K   Kokudo Norihiro N  

International journal of surgery case reports 20150731


<h4>Introduction</h4>Portal vein thrombosis (PVT) after liver transplantation (LT) is one of serious complications and reportedly ranges from 2% to 13%. PVT impairs the blood perfusion to the grafts and causes the graft dysfunction.<h4>Presentation of case</h4>A 60-year-old female underwent living-donor LT with the left liver graft for end-stage liver disease related to chronic hepatitis C. After reperfusion, Indocyanine green (ICG)-fluorescence imaging was performed to confirm the graft perfusi  ...[more]

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