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Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene.


ABSTRACT: 2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.

SUBMITTER: Shen PX 

PROVIDER: S-EPMC4573956 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other

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Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene.

Shen Peng-Xiang PX   Wang Xiao-Chen XC   Wang Peng P   Zhu Ru-Yi RY   Yu Jin-Quan JQ  

Journal of the American Chemical Society 20150903 36


2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed. ...[more]

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