GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder.
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ABSTRACT:
SUBMITTER: Gan-Or Z
PROVIDER: S-EPMC4574811 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Publications
GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder.
Gan-Or Ziv Z Mirelman Anat A Postuma Ronald B RB Arnulf Isabelle I Bar-Shira Anat A Dauvilliers Yves Y Desautels Alex A Gagnon Jean-François JF Leblond Claire S CS Frauscher Birgit B Alcalay Roy N RN Saunders-Pullman Rachel R Bressman Susan B SB Marder Karen K Monaca Christelle C Högl Birgit B Orr-Urtreger Avi A Dion Patrick A PA Montplaisir Jacques Y JY Giladi Nir N Rouleau Guy A GA
Annals of clinical and translational neurology 20150731 9
Rapid eye movement sleep behavior disorder and GBA mutations are both associated with Parkinson's disease. The GBA gene was sequenced in idiopathic rapid eye movement sleep behavior disorder patients (n = 265), and compared to controls (n = 2240). Rapid eye movement sleep behavior disorder questionnaire was performed in an independent Parkinson's disease cohort (n = 120). GBA mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, P < 0.0001) for rapid eye movement sleep be ...[more]
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