Unknown

Dataset Information

0

Regulatory T cells turn pathogenic.

ABSTRACT: Foxp3(+) regulatory T (Treg) cells are considered a sub-lineage of CD4(+) T cells that are protective against autoimmunity due to their essential roles in maintaining immune homeostasis and self-tolerance. However, Treg cells are unstable in vivo in terms of lineage specialization and suppressive function. These unstable Treg cells play roles in the pathogenesis of diseases, which cause safety concerns regarding human Treg cell therapy. In this review, we highlight recent findings that demonstrate the pathogenic conversion of Treg cells in different disease models.

SUBMITTER: Guo J 

PROVIDER: S-EPMC4579652 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other

Json Xml

Similar Datasets

Unknown Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells.
| S-EPMC3606805 | biostudies-literature
Unknown Artemether Does Not Turn ? Cells into ? Cells.
| S-EPMC5762275 | biostudies-literature
Unknown Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells.
| S-EPMC4322772 | biostudies-literature
Unknown MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells.
| S-EPMC4104030 | biostudies-literature
Unknown Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.
| S-EPMC518661 | biostudies-literature
Unknown Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes.
| S-EPMC6483657 | biostudies-literature
Unknown The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease.
| S-EPMC4002916 | biostudies-other
Unknown IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy.
| S-EPMC3537488 | biostudies-other
Unknown STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs.
| S-EPMC7529787 | biostudies-literature
Unknown Regulatory roles of phosphorylation in model and pathogenic fungi.
| S-EPMC4818690 | biostudies-literature