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Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children.

ABSTRACT: Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism.We used multivariable linear regression and a negative control design to examine offspring epigenome-wide DNA methylation in relation to maternal and offspring adiposity in 1018 participants.Compared with neonatal offspring of normal weight mothers, 28 and 1621 CpG sites were differentially methylated in offspring of obese and underweight mothers, respectively [false discovert rate (FDR)-corrected P-value?

SUBMITTER: Sharp GC 

PROVIDER: S-EPMC4588865 | biostudies-other | 2015 Aug

REPOSITORIES: biostudies-other

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Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children.

Sharp Gemma C GC   Lawlor Debbie A DA   Richmond Rebecca C RC   Fraser Abigail A   Simpkin Andrew A   Suderman Matthew M   Shihab Hashem A HA   Lyttleton Oliver O   McArdle Wendy W   Ring Susan M SM   Gaunt Tom R TR   Davey Smith George G   Relton Caroline L CL  

International journal of epidemiology 20150408 4

<h4>Background</h4>Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism.<h4>Methods</h4>We used multivariable linear regression and a negative control design to examine offspring epigenome-wide DNA methylation in relation to maternal and offspring adiposity in 1018 participants.<h4>Results</h4>Compared with neonatal offspring of normal weight mothers, 28 and 1621  ...[more]