Ontology highlight
ABSTRACT:
SUBMITTER: Jimenez Calvente C
PROVIDER: S-EPMC4589454 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Hepatology (Baltimore, Md.) 20150828 4
<h4>Unlabelled</h4>Fibrosis accompanies the wound-healing response to chronic liver injury and is characterized by excessive hepatic collagen accumulation dominated by collagen type I. Fibrosis often progresses to cirrhosis. Here we present in vivo evidence of an up to 90% suppression of procollagen α1(I) expression, a reduction of septa formation, and a 40%-60% decrease of collagen deposition in mice with progressive and advanced liver fibrosis that received cationic lipid nanoparticles loaded ...[more]