Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene.
Ontology highlight
ABSTRACT:
SUBMITTER: Nithianantharajah J
PROVIDER: S-EPMC4589696 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Publications
Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene.
Nithianantharajah J J McKechanie A G AG Stewart T J TJ Johnstone M M Blackwood D H DH St Clair D D Grant S G N SG Bussey T J TJ Saksida L M LM
Scientific reports 20151001
Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic. ...[more]
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