The B-cell antigen receptor integrates adaptive and innate immune signals.

ABSTRACT: B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response.

SUBMITTER: Otipoby KL 

PROVIDER: S-EPMC4593120 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other