Ontology highlight
ABSTRACT:
SUBMITTER: Wright BD
PROVIDER: S-EPMC4593509 | biostudies-other | 2015 Jul
REPOSITORIES: biostudies-other
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 20150213 7
The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-smallcell lung cancer cell lines. Several of these complexes displayed anticancer activity comparable to cisplatin. These compounds induced apoptosis in the NCI-H460 cell line as determined by Annexin V staining, caspase-3, and PAR ...[more]