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Vesicular control of fusion pore expansion.


ABSTRACT: Exocytic post-fusion events play an important role determining the composition and quantity of cellular secretion. In particular, Ca(2+)-dependent regulation of fusion pore dilation/closure is a key regulator for fine-tuning vesicle content secretion. This requires a tight temporal and spatial integration of vesicle fusion with the PM, Ca(2+) signals and translation of the Ca(2+) signal into fusion pore dilation via auxiliary factors. Yet, it is still mostly elusive how this is achieved in slow and non-excitable secretory cells, where initial Ca(2+) signals triggering fusions will abate before onset of the post-fusion phase. New results suggest, that the vesicles themselves provide the necessary itinerary to sense and link vesicle fusion to generation of local Ca(2+) signals and fusion pore expansion.

SUBMITTER: Neuland K 

PROVIDER: S-EPMC4594593 | biostudies-other | 2015 Mar-Apr

REPOSITORIES: biostudies-other

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