Ontology highlight
ABSTRACT:
SUBMITTER: Victoria-Acosta G
PROVIDER: S-EPMC4595840 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Scientific reports 20151007
XAF1 is a tumour suppressor gene that compromises cell viability by modulating different cellular events such as mitosis, cell cycle progression and apoptosis. In cancer, the XAF1 gene is commonly silenced by CpG-dinucleotide hypermethylation of its promoter. DNA demethylating agents induce transcriptional reactivation of XAF1, sensitizing cancer cells to therapy. The molecular mechanisms that mediate promoter CpG methylation have not been previously studied. Here, we demonstrate that CTCF inter ...[more]