Ontology highlight
ABSTRACT:
SUBMITTER: Marshall OJ
PROVIDER: S-EPMC4595905 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Bioinformatics (Oxford, England) 20150625 20
<h4>Unlabelled</h4>DamID is a powerful technique for identifying regions of the genome bound by a DNA-binding (or DNA-associated) protein. Currently, no method exists for automatically processing next-generation sequencing DamID (DamID-seq) data, and the use of DamID-seq datasets with normalization based on read-counts alone can lead to high background and the loss of bound signal. DamID-seq thus presents novel challenges in terms of normalization and background minimization. We describe here da ...[more]