Alcoholic Liver Disease: Role of Cytokines.
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ABSTRACT:
SUBMITTER: Neuman MG
PROVIDER: S-EPMC4598786 | biostudies-other | 2015 Aug
REPOSITORIES: biostudies-other
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Alcoholic Liver Disease: Role of Cytokines.
Neuman Manuela G MG Maor Yaakov Y Nanau Radu M RM Melzer Ehud E Mell Haim H Opris Mihai M Cohen Lawrence L Malnick Stephen S
Biomolecules 20150828 3
The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical and translational research. It focuses on the role of the immune system and the signaling pathways of cytokines in the pathogenesis of ALD. An additional factor that contributes to the pathogenesis of ALD is lipopolysaccharide (LPS), which plays a central role in the induction of steatosis, inflammation, and fibrosis in the liver. LPS derived from the intestinal microbiota enters th ...[more]
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