Ontology highlight
ABSTRACT:
SUBMITTER: Cook KL
PROVIDER: S-EPMC4600199 | biostudies-other | 2015 Aug
REPOSITORIES: biostudies-other
Future medicinal chemistry 20150824 12
Over 230,000 new cases of invasive breast cancer are diagnosed annually within the USA. Recurrent breast cancer remains a mostly incurable disease with drug resistance, tumor latency and distant metastases driving breast tumor recurrence and morbidity. Understanding drug resistance is a critical component of combating breast cancer. Recently, the protein chaperone GRP78 and the unfolded protein response were implicated as drivers of drug resistance. Preclinical studies show inhibiting GRP78 can ...[more]