Ontology highlight
ABSTRACT:
SUBMITTER: Nors Perdersen M
PROVIDER: S-EPMC4603703 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Nors Perdersen Martin M Foderà Vito V Horvath Istvan I van Maarschalkerweerd Andreas A Nørgaard Toft Katrine K Weise Christoph C Almqvist Fredrik F Wolf-Watz Magnus M Wittung-Stafshede Pernilla P Vestergaard Bente B
Scientific reports 20150528
Aggregation of proteins into amyloid deposits is the hallmark of several neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The suggestion that intermediate oligomeric species may be cytotoxic has led to intensified investigations of pre-fibrillar oligomers, which are complicated by their transient nature and low population. Here we investigate alpha-synuclein oligomers, enriched by a 2-pyridone molecule (FN075), and the conversion of oligomers into fibrils. As probed by lea ...[more]